In 1928, after Barbara Griffiths, age four, strayed into the woods surrounding the upstate village of Massena, New York, the allegation of ritual murder, known to Jews as "blood libel", took hold. Historian Edward Berenson, himself a native of Massena, sheds light on the cross-cultural forces that ignited America's only known instance of blood libel, and traces its roots in Old World prejudice, homegrown antisemitism, and the resurgence of the Ku Klux Klan in the 1920s. Residues of all three have persisted until the present day.