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The Gene: An Intimate History (2016)

Tekijä: Siddhartha Mukherjee

Muut tekijät: Katso muut tekijät -osio.

JäseniäKirja-arvostelujaSuosituimmuussijaKeskimääräinen arvioMaininnat
2,525735,781 (4.21)123
History. Medical. Sociology. Nonfiction. HTML:2017 Audie Award Finalist for Non-Fiction
The #1 NEW YORK TIMES Bestseller
The basis for the PBS Ken Burns Documentary The Gene: An Intimate History

From the Pulitzer Prize??winning author of The Emperor of All Maladies??a fascinating history of the gene and "a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick" (Elle).

"Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." ??Ken Burns
"Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost" (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

"Mukherjee expresses abstract intellectual ideas through emotional stories...[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry" (The Washington Post). Throughout, the story of Mukherjee's own family??with its tragic and bewildering history of mental illness??reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation??from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

"A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are??and what our manipulation of those genes might mean for our future" (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. "The Gene is a book we all should read
… (lisätietoja)
Viimeisimmät tallentajatPICHBOOK, yates9, liz101, roshanraju, bgmadigan, EliasKraushaar, yksityinen kirjasto, Cassita, MarkChia, joshgesler
  1. 10
    p53: The Gene that Cracked the Cancer Code (tekijä: Sue Armstrong) (rodneyvc)
  2. 00
    Lyhyt historia meistä kaikista: Ihmiskunnan tarina geenien kertomana (tekijä: Adam Rutherford) (jigarpatel)
    jigarpatel: Summary of how humans have evolved with evidence found in genetics; interesting follow-up to Gene: An Intimate History.
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englanti (71)  ranska (2)  Kaikki kielet (73)
Näyttää 1-5 (yhteensä 73) (seuraava | näytä kaikki)
Dear Dr. Mukerjee,

Thanks for the great update on what's going on in the genetics business. Just another reason for me to encourage my daughter to consider a career in biology or cellular biology or evolutionary biology. As we turn our attention to the little world under the microscope we see even more variety and complexity than we could have imagined....even 30 years ago. I couldn't agree with you more that I should be a little worried that scientists are plowing ahead with experiments genetically altering human embryos and accidentally creating unexpected mutations. While we learn more about genes influencing specific diseases these relationships are rarely one-to-one, have relationships contingent on the environment, and generally don't lend themselves to, ahem, cut-and-paste. I want to believe that gene therapy will yield big dividends for human health, reducing misery in the world, and promoting long useful lives. Genes, like leaves of grass, have a much longer evolutionary life than do humans. Bacteria, viruses also have been fighting the good fight for survival much, much longer than humans. And so I think fruitful to ask again, to what degree are we the masters of our fate, even when we monkey with the gene pool? I'll be staying up late nights to ponder that conundrum. ( )
  MylesKesten | Jan 23, 2024 |
Un libro magnifico y maravilloso, una historia (del gen) impresionante, contada de una forma simplemente magistral. Después de leer este libro cambia (o reafirma) tu forma de ver la vida. Disfrute tanto leerlo!! (cuanto me hubiera gustado podérselo recomendar a mi padre para platicar/comentarlo con el). ( )
  keplerhc | Jan 22, 2024 |
Siddhartha Mukherjee has that rare quality of making it sound like he’s cramming a bucketload of information in his words, all the while not losing brevity. In The Emperor of All Maladies, this quality was suppressed – the topic of cancer is weighty, and thus brevity was preserved over information density. This quality is out in full force in Gene, so you must take a breather every fifty or sixty pages.
Genecovers so much information about genetics that after finishing it, you will feel that you have absorbed those information pellets sometimes found in science fiction. It follows a similar pathway to The Emperor, with Mukherjee tracking the story of genetics from its ancestors (including debunked theories such as the sperm-containing mini-children) to the present, where we’re making quantum leaps in the field every few years.
Aside from its remarkable history, the novel delves into the gene and what makes it tick. For example - how mutations mess with (or improve) a genome, how DNA can be combined to form recombinant DNA not generally found on a genome, how gene editing works, and how our genome can have a genetic ‘memory’ of sorts.
More soberly, however, Mukherjee illuminates the reader with digressions centred on his family – and how mental illness was so pervasive in his family. It lends the entire novel a human touch that you cannot help but reflect on. Saying that the gene has been at the forefront of modern is something else, but saying that it has impacted the author’s life brings it into some perspective – not missing the trees for the forest, if you will.
Gene is a rich and illuminating history of genetics and digressions into its probable future. I am not sure where genetics will land in even twenty years – but I now know watching the field progress will be breathtaking. ( )
  SidKhanooja | Sep 1, 2023 |
Engaging and readable, neither dumbed-down nor densely academic. Very interesting to get an overview of developments since I left uni (and of everything I didn't learn there as well). ( )
1 ääni Kiramke | Jun 27, 2023 |
Science writing for the general reader done as it should be done - detailed, accurate, and engaging. It's a big book, and the reading is necessarily slow, but worth the effort. ( )
  mbmackay | Jan 25, 2023 |
Näyttää 1-5 (yhteensä 73) (seuraava | näytä kaikki)
The story of this invention and this discovery has been told, piecemeal, in different ways, but never before with the scope and grandeur that Siddhartha Mukherjee brings to his new history, “The Gene.” ... As he did in his Pulitzer ­Prize-winning history of cancer, “The Emperor of All Maladies” (2010), Mukherjee views his subject panoptically, from a great and clarifying height, yet also intimately.
 
... By the time “The Gene” is over, Dr. Mukherjee has covered Mendel and his peas, Darwin and his finches. He’s taken us on the quest of Watson, Crick and their many unsung compatriots to determine the stuff and structure of DNA. We learn about how genes were sequenced, cloned and variously altered, and about the race to map our complete set of DNA, or genome, which turns out to contain a stunning amount of filler material with no determined function.

...Many of the same qualities that made “The Emperor of All Maladies” so pleasurable are in full bloom in “The Gene.” The book is compassionate, tautly synthesized, packed with unfamiliar details about familiar people....

... “The Gene” is more pedagogical than dramatic; as often as not, the stars of this story are molecules, not humans. Dr. Mukherjee still has a poignant personal connection to the material — mental illness has wrapped itself around his family tree like a stubborn vine, claiming two uncles and a cousin on his father’s side — but this book does not aim for the gut. It aims for the mind...
 

» Lisää muita tekijöitä (4 mahdollista)

Tekijän nimiRooliTekijän tyyppiKoskeeko teosta?Tila
Siddhartha Mukherjeeensisijainen tekijäkaikki painoksetlaskettu
Boutsikaris, DennisKertojamuu tekijäeräät painoksetvahvistettu
Drost-Plegt, TraceyKääntäjämuu tekijäeräät painoksetvahvistettu
Veen, René vanKääntäjämuu tekijäeräät painoksetvahvistettu
Sinun täytyy kirjautua sisään voidaksesi muokata Yhteistä tietoa
Katso lisäohjeita Common Knowledge -sivuilta (englanniksi).
Teoksen kanoninen nimi
Alkuteoksen nimi
Teoksen muut nimet
Alkuperäinen julkaisuvuosi
Henkilöt/hahmot
Tiedot englanninkielisestä Yhteisestä tiedosta. Muokkaa kotoistaaksesi se omalle kielellesi.
Tärkeät paikat
Tärkeät tapahtumat
Kirjaan liittyvät elokuvat
Epigrafi (motto tai mietelause kirjan alussa)
Tiedot englanninkielisestä Yhteisestä tiedosta. Muokkaa kotoistaaksesi se omalle kielellesi.
An exact determination of the laws of heredity will probably work more change in man's outlook on the world, and in his power over nature, than any other advance in natural knowledge that can be foreseen.
—William Bateson
Human beings are ultimately nothing but carriers—passageways—for genes.  They ride us into the ground like racehorses from generation to generation.  Genes don't think about what constitutes good or evil.  They don't care whether we are happy or unhappy.  We're just means to an end for them.  The only thing they think about is what is most efficient for them.
—Haruki Murakami, IQ84
Omistuskirjoitus
Tiedot englanninkielisestä Yhteisestä tiedosta. Muokkaa kotoistaaksesi se omalle kielellesi.
To Priyabala Mukherjee (1906-1985), who knew the perils;
to Carrie Buck (1906-1983), who experienced them.
Ensimmäiset sanat
Tiedot englanninkielisestä Yhteisestä tiedosta. Muokkaa kotoistaaksesi se omalle kielellesi.
Prologue
In the winter of 2012, I traveled from Delhi to Calcutta to visit my cousin Moni.
The monastery was originally a nunnery.
Sitaatit
Viimeiset sanat
Tiedot englanninkielisestä Yhteisestä tiedosta. Muokkaa kotoistaaksesi se omalle kielellesi.
(Napsauta nähdäksesi. Varoitus: voi sisältää juonipaljastuksia)
Erotteluhuomautus
Julkaisutoimittajat
Kirjan kehujat
Tiedot englanninkielisestä Yhteisestä tiedosta. Muokkaa kotoistaaksesi se omalle kielellesi.
Alkuteoksen kieli
Tiedot englanninkielisestä Yhteisestä tiedosta. Muokkaa kotoistaaksesi se omalle kielellesi.
Kanoninen DDC/MDS
Kanoninen LCC

Viittaukset tähän teokseen muissa lähteissä.

Englanninkielinen Wikipedia (1)

History. Medical. Sociology. Nonfiction. HTML:2017 Audie Award Finalist for Non-Fiction
The #1 NEW YORK TIMES Bestseller
The basis for the PBS Ken Burns Documentary The Gene: An Intimate History

From the Pulitzer Prize??winning author of The Emperor of All Maladies??a fascinating history of the gene and "a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick" (Elle).

"Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." ??Ken Burns
"Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost" (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

"Mukherjee expresses abstract intellectual ideas through emotional stories...[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry" (The Washington Post). Throughout, the story of Mukherjee's own family??with its tragic and bewildering history of mental illness??reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation??from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

"A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are??and what our manipulation of those genes might mean for our future" (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. "The Gene is a book we all should read

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